{"id":2,"date":"2017-12-12T22:04:31","date_gmt":"2017-12-12T22:04:31","guid":{"rendered":"https:\/\/primmunerx.wpengine.com\/?page_id=2"},"modified":"2024-02-23T09:17:04","modified_gmt":"2024-02-23T17:17:04","slug":"home","status":"publish","type":"page","link":"https:\/\/www.primmunerx.com\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; module_id=&#8221;about&#8221; _builder_version=&#8221;4.21.0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_code _builder_version=&#8221;4.21.0&#8243; global_colors_info=&#8221;{}&#8221;]\n\t\t\t<!-- START HP Banner REVOLUTION SLIDER 6.6.20 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_1_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_1_1\" style=\"\" data-version=\"6.6.20\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-1\" data-title=\"Slide\" data-anim=\"ms:600;r:0;\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"Slide\" title=\"Home\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/transparent.png\" data-bg=\"c:#f68f18;\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><a\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-1\" \n\t\t\t\t\t\t\t\tclass=\"rs-layer\"\n\t\t\t\t\t\t\t\thref=\"#science\" target=\"_self\"\n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#750c49\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;y:b;\"\n\t\t\t\t\t\t\t\tdata-text=\"s:40;l:22;fw:800;a:center;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:24px;h:39px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"sp:450;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8540;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:7;font-family:'Open Sans';\"\n\t\t\t\t\t\t\t><i class=\"fa-angle-down\" style=\"font-weight:bold;\"><\/i> \n\t\t\t\t\t\t\t<\/a><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-3\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:-655px,-655px,-655px,-432px;yo:-253px,-253px,-253px,-1919px;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:1180px;h:900px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:left;o:1;rZ:-160;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"rZ:-160;sp:1000;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7990;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:6;background-color:#4a525a;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-4\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:3px,3px,3px,-381px;yo:58px,58px,58px,-578px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:35,35,35,40;l:39,39,39,50;ls:-1px;fw:900;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:546px,546px,546px,495px;h:auto,auto,auto,93px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:760;sp:1010;sR:760;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7230;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:8;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Harnessing Innate Immunity \nto Treat Cancer\n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-5\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:1px,1px,1px,-639px;yo:149px,149px,149px,-833px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:18,18,18,17;l:28,28,28,25;ls:normal,normal,normal,0px;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:481px,481px,481px,488px;h:auto,auto,auto,126px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:530;sp:1050;sR:530;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7420;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:9;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Founded by experts in oral small molecule structure-based drug design and immune agonist pharmacology, Primmune is focused on improving the outcomes for patients with cancers by activating plasmacytoid dendritic cells (pDCs) via the toll-like receptor 7 (TLR7) pathway.  Primmune\u2019s lead candidate, PRTX007, has been specifically designed to activate the desired components of innate immunity and downstream adaptive immune response while avoiding biosynthesis of pro-inflammatory factors.  Our belief is that PRTX007 in combination with existing immunotherapies, can improve response rates and treatment durability. \n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-6\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,l,l,c;xo:372px,372px,372px,0;yo:-491px,-491px,-491px,18px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:40,40,40,23;l:50,50,50,29;ls:-1px,-1px,-1px,0;fw:900;a:inherit,inherit,inherit,left;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:495px,495px,495px,399px;h:93px,93px,93px,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:780;sp:630;sR:780;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7590;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:10;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Harnessing Innate Immunity \nto Treat Cancer and Viral Infections \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-7\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,l,l,c;xo:-235px,-235px,-235px,0;y:t,t,t,m;yo:-630px,-630px,-630px,-137px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:17,17,17,14;l:25,25,25,20;ls:0px,0px,0px,0;a:inherit,inherit,inherit,left;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:488px,488px,488px,394px;h:126px,126px,126px,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:850;sp:630;sR:850;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7520;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:11;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Founded by experts in structure-based drug design, Primmune was established for the express purpose\nof solving issues that have prevented successful targeting of the TLR7 pathway for therapeutic benefit\nin systemic human diseases. \u201cTuned\u201d TLR7 agonists have been specifically designed to activate the\ndesired components of innate immunity and downstream adaptive immune response while avoiding\nbiosynthesis of pro-inflammatory factors. The result is the creation of a portfolio of TLR7 agonists that\nprovide well-tolerated, controlled, long-term stimulation of the innate immune response while also\npotentiating long-term and effective innate and adaptive immune responses. <strong>Primmune\u2019s lead candidate, PRTX007 is\nthe most selective and tolerable clinical stage novel oral TLR7 agonist in clinical development globally.<\/strong>\n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-8\" \n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:r,r,r,c;xo:-29px,-29px,-29px,0;y:m,m,m,b;yo:-678px,-678px,-678px,30px;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:408px,408px,408px,286px;h:330px,330px,330px,231px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"e:easeInQuart;sp:2240;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6750;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:12;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"408\" height=\"330\" data-lazyload=\"\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/genes.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-9\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:-1470px,-1470px,-1470px,-331px;yo:-1795px,-1795px,-1795px,-463px;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:1180px;h:900px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;rZ:-160;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"rZ:-160;sp:1000;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7990;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:5;background-color:#4a525a;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-10\" \n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:564px;y:m;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:['408px','408px','408px','408px'];h:['330px','330px','330px','330px'];\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"e:easeInQuint;sp:2200;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6790;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:13;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"408\" height=\"330\" data-lazyload=\"\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/genes.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script>\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_1_1',rl:[1240,1240,1240,480],el:[519,519,519,720],gw:[974,974,974,480],gh:[519,519,519,720],type:'standard',justify:'',layout:'fullwidth',mh:\"0\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"revslider11\"]!==undefined) {window.RS_MODULES.modules[\"revslider11\"].once = false;window.revapi1 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.21.0&#8243; background_image=&#8221;https:\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/wave.jpg&#8221; parallax=&#8221;on&#8221; custom_padding=&#8221;200px||200px|&#8221; custom_padding_tablet=&#8221;100px||100px|&#8221; custom_padding_phone=&#8221;25px||25px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_code _builder_version=&#8221;4.21.0&#8243; custom_padding=&#8221;100px||100px|&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;off|desktop&#8221; module_id=&#8221;science&#8221; _builder_version=&#8221;4.21.0&#8243; background_color=&#8221;#edeae6&#8243; custom_padding_phone=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.21.0&#8243; width=&#8221;89%&#8221; 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_builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/primmune.png&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;35px|||&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.21.0&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Science&#8221; _builder_version=&#8221;4.21.0&#8243; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>The Importance of Plasmacytoid Dendritic Cells (pDCs)<\/h2>\n<p>Plasmacytoid dendritic cells are immune cells that are activated by the presence of viral infections or tumor cells.  The detection of viral infections or tumor cells is carried out by a narrow set of proteins, including toll-like receptors (TLRs) such as TLR7, which activate pDCs.  Once activated, pDCs mediate direct killing of tumor cells by the production of soluble factors including Type I and III IFN\u2019s as well as therapeutic engagement of NK cells and other elements of the antitumor innate immune response. Activated pDC\u2019s also drive a coordinated adaptive immune response resulting in the activation of cytotoxic T cells and the downstream differentiation of Th1 cells which is critical to long-term disease control.  <\/p>\n<p>Systemic activation of pDCs is especially important as this provides a benefit to cancer treatment in two important ways: first by reversing immunosuppression by exhausted pDCs in the tumor microenvironment and secondly by initiating surveillance by activating circulating pDCs.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16.0&#8243; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;||0px||false|false&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;0px||0px|&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Pipeline: PRX007&#8243; _builder_version=&#8221;4.21.0&#8243; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;0px||0px|&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; link_option_url=&#8221;https:\/\/www.primmunerx.com\/publications\/&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>PRTX007: Clinical Validation of Primmune\u2019s TLR7 Agonist<\/h2>\n<p><p>PRTX007 is a tuned TLR7 agonist and Primmune\u2019s lead clinical development candidate. <strong>PRTX007 is administered orally and uniquely activates pDCs, leading to a systemic immune poly-IFN response without stimulating systemic production of NF-\u03baB driven proinflammatory factors like IL-6, TNF\u03b1 or IL-1\u03b2. <\/strong> Activated pDCs directly deliver interferons to target cells by paracrine transfer; functionally equivalent to administering a cocktail of all Type I\/III IFN while avoiding the associated side effects and adverse events.<\/p>\n<p>Preclinical data for PRTX007 have demonstrated the systemic distribution and activation of target cells and the ability to maintain immune pressure without activating systemic proinflammatory cytokines.<strong><a href=\"https:\/\/www.primmunerx.com\/wp-content\/uploads\/2023\/08\/Primmune_AACR20222023_Poster_4.4.23_Final.pdf\" target=\"_blank\" rel=\"noopener\"> Published interim clinical data<\/a><\/strong> from the PRTX007 first-in-human (FIH) study in healthy volunteers demonstrates: <\/p>\n<ul id=\"thera_list\">\n<li><i class=\"fa fa-check\" aria-hidden=\"true\"><\/i>A favorable safety profile; no apparent overlapping mechanistic toxicity with that of known checkpoint inhibitors\n<\/li>\n<li><i class=\"fa fa-check\" aria-hidden=\"true\"><\/i>Dose-dependent systemic exposure and activation of the innate immune response without production of proinflammatory cytokines<\/li>\n<li><i class=\"fa fa-check\" aria-hidden=\"true\"><\/i>Breadth of immune induction and a coordinated downstream adaptive immune response<\/li>\n<\/ul>\n<p><strong><a href=\"https:\/\/www.primmunerx.com\/publications\/\" target=\"_blank\" rel=\"noopener\">Click here<\/a> <\/strong>for publications highlighting Primmune\u2019s published clinical data.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;therapeutics&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;#edeae6&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;0px||0px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Therapeutic Focus&#8221; _builder_version=&#8221;4.21.0&#8243; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Primmune\u2019s Therapeutic Focus &#8211; Virally-Mediated Cancers<\/h2>\n<p>The global burden of HPV-caused cancers is significant and includes cervical, vaginal, vulvar, penile, anal and oropharynx cancers.  The U.S. incidence of oropharyngeal cancers alone is >54,000 new cases per year.  More than 70% of oropharyngeal cancers are caused by HPV and while vaccination has been helpful, it\u2019s not expected to reverse the increasing rates of oropharyngeal cancers until well after the year 2045. <\/p>\n<p>Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide.  The U.S. incidence of HCC is >47,000 new cases per year and is expected to grow 55% by the year 2050.  The primary cause of HCC in the U.S. is Hepatitis C (HCV).  While there is a treatment for HCV, 75% of individuals who have HCV are unaware that they have it and only 1 in 3 individuals infected with HCV have been cured in the 10 years since direct-acting antiviral treatment has been available.  Hepatitis B (HBV) is also a cause of HCC despite the availability of the HBV vaccine since the early 1980\u2019s.<\/p>\n<p>PRTX007 is being rapidly advanced towards clinical trials for HPV-caused oropharyngeal cancer and HCC. <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;team&#8221; _builder_version=&#8221;4.16.0&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_stops=&#8221;#f8f7f9 51%|#d2c9c8 100%&#8221; background_color_gradient_start=&#8221;#f8f7f9&#8243; background_color_gradient_start_position=&#8221;51%&#8221; background_color_gradient_end=&#8221;#d2c9c8&#8243; background_enable_image=&#8221;off&#8221; background_position=&#8221;center_right&#8221; background_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;center&#8221; custom_padding=&#8221;60px||||false|false&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;10px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Team&#8221; _builder_version=&#8221;4.21.0&#8243; custom_padding=&#8221;||60px|&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;||0px||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Team<\/h2>\n<p>Our team is committed to the invention of new medicines to treat people suffering from cancer and to create substantial value for our investors and partners. We have comprehensive experience in the science and business of drug discovery, development, and commercialization.<\/p>\n<div class=\"btn\"><a href=\"https:\/\/www.primmunerx.com\/team\/\">Meet The Team \u00bb<\/a><\/div>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/primmune-team.png&#8221; title_text=&#8221;primmune-team&#8221; show_bottom_space=&#8221;off&#8221; align=&#8221;center&#8221; force_fullwidth=&#8221;on&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16.0&#8243; transform_scale_tablet=&#8221;&#8221; transform_scale_phone=&#8221;&#8221; transform_scale_last_edited=&#8221;on|desktop&#8221; transform_translate_tablet=&#8221;&#8221; transform_translate_phone=&#8221;0px|-10px&#8221; transform_translate_last_edited=&#8221;on|phone&#8221; transform_translate_linked_phone=&#8221;off&#8221; transform_rotate_tablet=&#8221;&#8221; transform_rotate_phone=&#8221;&#8221; transform_rotate_last_edited=&#8221;on|desktop&#8221; transform_skew_tablet=&#8221;&#8221; transform_skew_phone=&#8221;&#8221; transform_skew_last_edited=&#8221;on|desktop&#8221; transform_origin_tablet=&#8221;&#8221; transform_origin_phone=&#8221;&#8221; transform_origin_last_edited=&#8221;on|desktop&#8221; transform_styles_last_edited=&#8221;on|phone&#8221; animation_direction=&#8221;top&#8221; transform_styles_tablet=&#8221;&#8221; transform_styles_phone=&#8221;&#8221; custom_css_main_element=&#8221;position:relative; bottom:-10px;&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;contact&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#4a525a&#8221; custom_padding=&#8221;24px||24px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;0px||0px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Contact&#8221; _builder_version=&#8221;4.24.0&#8243; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Contact Us<\/h2>\n<p>Primmune Therapeutics, Inc.<br \/>\n2011 Palomar Airport Rd, Suite 101<br \/>\nCarlsbad CA 92011<\/p>\n<p>\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f154-o1\" lang=\"en\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/wp-json\/wp\/v2\/pages\/2#wpcf7-f154-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"154\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.9.3\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f154-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-name\"><input size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Name\" value=\"\" type=\"text\" name=\"your-name\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" class=\"wpcf7-form-control wpcf7-email wpcf7-validates-as-required wpcf7-text wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Email\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Message\" name=\"your-message\"><\/textarea><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap\" data-name=\"newsletter-signup\"><span class=\"wpcf7-form-control wpcf7-checkbox\"><span class=\"wpcf7-list-item first last\"><input type=\"checkbox\" name=\"newsletter-signup[]\" value=\"Sign up for news\" \/><span class=\"wpcf7-list-item-label\">Sign up for news<\/span><\/span><\/span><\/span>\n<\/p>\n<div class=\"btn\">\n\t<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner\" id=\"form_submit\" type=\"submit\" value=\"Submit \u00bb\" \/>\n\t<\/p>\n<\/div><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\n\t\t\t<!-- START HP Banner REVOLUTION SLIDER 6.6.20 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_1_2_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_1_2\" style=\"\" data-version=\"6.6.20\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-1\" data-title=\"Slide\" data-anim=\"ms:600;r:0;\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"Slide\" title=\"Home\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/transparent.png\" data-bg=\"c:#f68f18;\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><a\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-1\" \n\t\t\t\t\t\t\t\tclass=\"rs-layer\"\n\t\t\t\t\t\t\t\thref=\"#science\" target=\"_self\"\n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#750c49\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;y:b;\"\n\t\t\t\t\t\t\t\tdata-text=\"s:40;l:22;fw:800;a:center;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:24px;h:39px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"sp:450;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8540;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:7;font-family:'Open Sans';\"\n\t\t\t\t\t\t\t><i class=\"fa-angle-down\" style=\"font-weight:bold;\"><\/i> \n\t\t\t\t\t\t\t<\/a><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-3\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:-655px,-655px,-655px,-432px;yo:-253px,-253px,-253px,-1919px;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:1180px;h:900px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:left;o:1;rZ:-160;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"rZ:-160;sp:1000;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7990;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:6;background-color:#4a525a;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-4\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:3px,3px,3px,-381px;yo:58px,58px,58px,-578px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:35,35,35,40;l:39,39,39,50;ls:-1px;fw:900;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:546px,546px,546px,495px;h:auto,auto,auto,93px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:760;sp:1010;sR:760;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7230;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:8;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Harnessing Innate Immunity \nto Treat Cancer\n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-5\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:1px,1px,1px,-639px;yo:149px,149px,149px,-833px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:18,18,18,17;l:28,28,28,25;ls:normal,normal,normal,0px;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:481px,481px,481px,488px;h:auto,auto,auto,126px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:530;sp:1050;sR:530;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7420;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:9;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Founded by experts in oral small molecule structure-based drug design and immune agonist pharmacology, Primmune is focused on improving the outcomes for patients with cancers by activating plasmacytoid dendritic cells (pDCs) via the toll-like receptor 7 (TLR7) pathway.  Primmune\u2019s lead candidate, PRTX007, has been specifically designed to activate the desired components of innate immunity and downstream adaptive immune response while avoiding biosynthesis of pro-inflammatory factors.  Our belief is that PRTX007 in combination with existing immunotherapies, can improve response rates and treatment durability. \n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-6\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,l,l,c;xo:372px,372px,372px,0;yo:-491px,-491px,-491px,18px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:40,40,40,23;l:50,50,50,29;ls:-1px,-1px,-1px,0;fw:900;a:inherit,inherit,inherit,left;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:495px,495px,495px,399px;h:93px,93px,93px,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:780;sp:630;sR:780;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7590;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:10;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Harnessing Innate Immunity \nto Treat Cancer and Viral Infections \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-7\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,l,l,c;xo:-235px,-235px,-235px,0;y:t,t,t,m;yo:-630px,-630px,-630px,-137px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:17,17,17,14;l:25,25,25,20;ls:0px,0px,0px,0;a:inherit,inherit,inherit,left;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:488px,488px,488px,394px;h:126px,126px,126px,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:850;sp:630;sR:850;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7520;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:11;font-family:'Lato';\"\n\t\t\t\t\t\t\t>Founded by experts in structure-based drug design, Primmune was established for the express purpose\nof solving issues that have prevented successful targeting of the TLR7 pathway for therapeutic benefit\nin systemic human diseases. \u201cTuned\u201d TLR7 agonists have been specifically designed to activate the\ndesired components of innate immunity and downstream adaptive immune response while avoiding\nbiosynthesis of pro-inflammatory factors. The result is the creation of a portfolio of TLR7 agonists that\nprovide well-tolerated, controlled, long-term stimulation of the innate immune response while also\npotentiating long-term and effective innate and adaptive immune responses. <strong>Primmune\u2019s lead candidate, PRTX007 is\nthe most selective and tolerable clinical stage novel oral TLR7 agonist in clinical development globally.<\/strong>\n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-8\" \n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:r,r,r,c;xo:-29px,-29px,-29px,0;y:m,m,m,b;yo:-678px,-678px,-678px,30px;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:408px,408px,408px,286px;h:330px,330px,330px,231px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"e:easeInQuart;sp:2240;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6750;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:12;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"408\" height=\"330\" data-lazyload=\"\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/genes.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-9\" \n\t\t\t\t\t\t\t\tclass=\"tp-shape tp-shapewrapper\"\n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:-1470px,-1470px,-1470px,-331px;yo:-1795px,-1795px,-1795px,-463px;\"\n\t\t\t\t\t\t\t\tdata-text=\"a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:1180px;h:900px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:top;o:1;rZ:-160;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"rZ:-160;sp:1000;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:7990;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:5;background-color:#4a525a;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-10\" \n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:564px;y:m;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:['408px','408px','408px','408px'];h:['330px','330px','330px','330px'];\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"e:easeInQuint;sp:2200;sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6790;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:13;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.primmunerx.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"408\" height=\"330\" data-lazyload=\"\/\/primmunerx.wpengine.com\/wp-content\/uploads\/2017\/12\/genes.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script>\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_1_2',rl:[1240,1240,1240,480],el:[519,519,519,720],gw:[974,974,974,480],gh:[519,519,519,720],type:'standard',justify:'',layout:'fullwidth',mh:\"0\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"revslider12\"]!==undefined) {window.RS_MODULES.modules[\"revslider12\"].once = false;window.revapi1_2 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\nThe Importance of Plasmacytoid Dendritic Cells (pDCs) Plasmacytoid dendritic cells are immune cells that are activated by the presence of viral infections or tumor cells. The detection of viral infections or tumor cells is carried out by a narrow set of proteins, including toll-like receptors (TLRs) such as TLR7, which activate pDCs. Once [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"<p>This is an example of a WordPress page, you could edit this to put information about yourself or your site so readers know where you are coming from. You can create as many pages like this one or sub-pages as you like and manage all of your content inside of WordPress.<\/p>","_et_gb_content_width":"","footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Home - Primmune<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.primmunerx.com\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home - Primmune\" \/>\n<meta property=\"og:description\" content=\"The Importance of Plasmacytoid Dendritic Cells (pDCs) Plasmacytoid dendritic cells are immune cells that are activated by the presence of viral infections or tumor cells. The detection of viral infections or tumor cells is carried out by a narrow set of proteins, including toll-like receptors (TLRs) such as TLR7, which activate pDCs. Once [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.primmunerx.com\/\" \/>\n<meta property=\"og:site_name\" content=\"Primmune\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Primmune-Therapeutics-1503521086370094\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-23T17:17:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@PrimmuneRx\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.primmunerx.com\/\",\"url\":\"https:\/\/www.primmunerx.com\/\",\"name\":\"Home - Primmune\",\"isPartOf\":{\"@id\":\"https:\/\/www.primmunerx.com\/#website\"},\"datePublished\":\"2017-12-12T22:04:31+00:00\",\"dateModified\":\"2024-02-23T17:17:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.primmunerx.com\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.primmunerx.com\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.primmunerx.com\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.primmunerx.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.primmunerx.com\/#website\",\"url\":\"https:\/\/www.primmunerx.com\/\",\"name\":\"Primmune\",\"description\":\"Primmune\",\"publisher\":{\"@id\":\"https:\/\/www.primmunerx.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.primmunerx.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.primmunerx.com\/#organization\",\"name\":\"Primmune Therapeutics\",\"url\":\"https:\/\/www.primmunerx.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.primmunerx.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.primmunerx.com\/wp-content\/uploads\/2017\/12\/Logo_2x.png\",\"contentUrl\":\"https:\/\/www.primmunerx.com\/wp-content\/uploads\/2017\/12\/Logo_2x.png\",\"width\":800,\"height\":168,\"caption\":\"Primmune Therapeutics\"},\"image\":{\"@id\":\"https:\/\/www.primmunerx.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/Primmune-Therapeutics-1503521086370094\/\",\"https:\/\/x.com\/PrimmuneRx\",\"https:\/\/www.linkedin.com\/company\/primmune-therapeutics\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Home - Primmune","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.primmunerx.com\/","og_locale":"en_US","og_type":"article","og_title":"Home - Primmune","og_description":"The Importance of Plasmacytoid Dendritic Cells (pDCs) Plasmacytoid dendritic cells are immune cells that are activated by the presence of viral infections or tumor cells. 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